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The Brunonian system of medicine is a theory of medicine which regards and treats disorders as caused by defective or excessive excitation. It was developed by the Scottish physician John Brown and is outlined in his 1780 publication Elementa Medicinae. It drew on the theories of his teacher William Cullen, but whereas Cullen set out to create a systematic nosology of diseases, Brown argued for a unified model in which all disease was related to stimulation.
Although Brown's theory never became very popular in Britain, it had temporary success in America, Italy, and the German-speaking part of Europe.